Document Detail


Magnetic PECA nanoparticles as drug carriers for targeted delivery: synthesis and release characteristics.
MedLine Citation:
PMID:  16754376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Magnetic poly(ethyl-2-cyanoacrylate) (PECA) nanoparticles containing anti-cancer drugs (Cisplatin and Gemcitabine) were prepared by inter-facial polymerization. The spherical nanoparticles (d = 250 +/- 15 nm) with smooth surfaces and moderately uniform size distributions were obtained. The amount of magnetite encapsulated inside the polymer matrix was increased up to 14.26% (w/w) by controlling the initial weight ratio of monomer/magnetite. It was found that the amount of Cisplatin encapsulated in the magnetic nanoparticle is much higher than that of Gemcitabine because Cisplatin (hydrophobic) is highly soluble in the oil phase and encapsulated easier inside nanoparticles compared to Gemcitabine (hydrophilic). The presence of magnetite and its super-paramagnetic characteristic were confirmed by FTIR spectra and VSM. In-vitro experiments of drug release and magnetic mobility under external magnetic field demonstrated that magnetic poly(ethyl-2-cyanoacrylate) (PECA) nanoparticles can be a highly versatile magnetic drug carrier with sustained release behaviour and sufficient magnetic susceptibility.
Authors:
J Yang; H Lee; W Hyung; S-B Park; S Haam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of microencapsulation     Volume:  23     ISSN:  0265-2048     ISO Abbreviation:  J Microencapsul     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-06-06     Completed Date:  2007-04-11     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  8500513     Medline TA:  J Microencapsul     Country:  England    
Other Details:
Languages:  eng     Pagination:  203-12     Citation Subset:  IM    
Affiliation:
Department of Chemical Engineering, College of Engineering, Yonsei University, Seoul, South Korea.
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MeSH Terms
Descriptor/Qualifier:
Cyanoacrylates / administration & dosage*,  chemistry
Drug Carriers*
Drug Delivery Systems*
Magnetics*
Microscopy, Electron, Scanning
Microscopy, Electron, Transmission
Nanoparticles* / ultrastructure
Nanotechnology / methods
Particle Size
Polymers / administration & dosage,  chemistry
Spectroscopy, Fourier Transform Infrared
Chemical
Reg. No./Substance:
0/Cyanoacrylates; 0/Drug Carriers; 0/Polymers; 7085-85-0/ethyl 2-cyanoacrylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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