| Magnetic Nanoparticles and microNMR for Diagnostic Applications. | |
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MedLine Citation:
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PMID: 22272219 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Sensitive and quantitative measurements of clinically relevant protein biomarkers, pathogens and cells in biological samples would be invaluable for disease diagnosis, monitoring of malignancy, and for evaluating therapy efficacy. Biosensing strategies using magnetic nanoparticles (MNPs) have recently received considerable attention, since they offer unique advantages over traditional detection methods. Specifically, because biological samples have negligible magnetic background, MNPs can be used to obtain highly sensitive measurements in minimally processed samples. This review focuses on the use of MNPs for in vitro detection of cellular biomarkers based on nuclear magnetic resonance (NMR) effects. This detection platform, termed diagnostic magnetic resonance (DMR), exploits MNPs as proximity sensors to modulate the spin-spin relaxation time of water molecules surrounding the molecularly-targeted nanoparticles. With new developments such as more effective MNP biosensors, advanced conjugational strategies, and highly sensitive miniaturized NMR systems, the DMR detection capabilities have been considerably improved. These developments have also enabled parallel and rapid measurements from small sample volumes and on a wide range of targets, including whole cells, proteins, DNA/mRNA, metabolites, drugs, viruses and bacteria. The DMR platform thus makes a robust and easy-to-use sensor system with broad applications in biomedicine, as well as clinical utility in point-of-care settings. |
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Authors:
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Huilin Shao; Changwook Min; David Issadore; Monty Liong; Tae-Jong Yoon; Ralph Weissleder; Hakho Lee |
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Publication Detail:
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Type: Journal Article Date: 2012-01-01 |
Journal Detail:
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Title: Theranostics Volume: 2 ISSN: 1838-7640 ISO Abbreviation: Theranostics Publication Date: 2012 |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101552395 Medline TA: Theranostics Country: Australia |
Other Details:
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Languages: eng Pagination: 55-65 Citation Subset: - |
Affiliation:
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1. Center for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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