Document Detail

Magnetic Microparticles for Endovascular Aneurysm Treatment: In-Vitro and In-Vivo Experimental Results.
MedLine Citation:
PMID:  21311370     Owner:  NLM     Status:  Publisher    
OBJECTIVE:: To test a novel embolisation material in experimental aneurysms in vitro and in vivo whereby intra-arterial administered magnetic microparticles are navigated into the lumen of vascular aneurysms with assistance from an external magnetic field. METHODS:: Magnetic Microparticles (MMPs) are Core-Shell Particles suspended in saline that have a shell made of a polymeric material and a core made of magnetite (Fe3O4). They have a diameter of 1,4 micrometers. During MMPs administration via a microcatheter, a magnetic field was applied externally to direct the particles employing a solid state neodymium magnet. Experiments were performed in a perfused silicone vessel and aneurysm model to evaluate application techniques and fluidodynamics and in the Elastase aneurysm model in rabbits to evaluate in vivo compatibility including multi-organ histological examinations and long-term stability of aneurysm embolisation. RESULTS:: It was possible to steer and hold the MMPs within the aneurismal cavity where they occluded the lumen progressively. After removal of the external magnetic field, in vivo the results remained stable for the remainder of the observational period (30 minutes), after a 12 week observational period, recanalization of the aneurysm occurred. CONCLUSION:: MMPs can be magnetically directed into aneurysms allowing short term obliteration. Although the method has yet to show reliable long term stability, these experiments provide the proof of concept encouraging further investigation of intravascular magnetic compounds.
Johanna Oechtering; Peter J Kirkpatrick; Alexander G K Ludolph; Franz J Hans; Bernd Sellhaus; Andreas Spiegelberg; Timo Krings
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-09
Journal Detail:
Title:  Neurosurgery     Volume:  -     ISSN:  1524-4040     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the 1Department of Neuroradiology, University Hospital Aachen, Germany, the 2Department of Neurology and Clinical Neurophysiology, Campus Benjamin Franklin, Charité - University Medicine Berlin, Germany, the 3Neurosurgical Unit, Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom, the 4Department of Radiology and Interventional Radiology, Municipal Hospital of Fulda, Germany, the 5Clinic for Neurosurgery, University Hospital Aachen, Germany, the 6Department of Neuropathology, University Hospital Aachen, Germany, 7Spiegelberg Gmbh & Co. KG Hamburg, Germany, and the 8Division of Neuroradiology, Department of Medical Imaging, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada.
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