| Magnesium(II)-binaphtholate as a practical chiral catalyst for the enantioselective direct Mannich-type reaction with malonates. | |
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MedLine Citation:
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PMID: 20608665 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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A highly enantioselective direct Mannich-type reaction of aldimines with dialkyl malonates was developed with the use of a Mg(II)-BINOLate salt, which was designed as a cooperative acid-base catalyst that can activate both aldimines and malonates. Optically active beta-aminoesters and alpha-halo-beta-aminoesters could be synthesized in high yields and with high enantioselectivities. This inexpensive and practical Mg(II)-BINOLate salt could be used in gram-scale catalysis. |
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Authors:
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Manabu Hatano; Takahiro Horibe; Kazuaki Ishihara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Organic letters Volume: 12 ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-30 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 3502-5 Citation Subset: - |
Affiliation:
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Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa, Nagoya, 464-8603, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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