Document Detail


Magnesium sulfate for tocolysis and risk of spastic cerebral palsy in premature children born to women without preeclampsia.
MedLine Citation:
PMID:  10992199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Our aim was to examine magnesium sulfate tocolysis and cerebral palsy in infants born prematurely to women without preeclampsia. STUDY DESIGN: We conducted a retrospective case-control study of infants with birth weights <1500 g and of infants with birth weights from 1500 to 1999 g who were born at <33 weeks' gestation. The study infants were born in level 2 or level 3 hospitals from 1988 through 1994 to women without preeclampsia, were delivered >3 hours after admission, and had survived to age 2 years. RESULTS: Among 170 children with cerebral palsy and 288 control subjects, similar proportions of case mothers (58%) and control mothers (62%) had received magnesium sulfate tocolysis. In women with some tocolytic treatment, these proportions were 78% and 76%, respectively. The duration of treatment with magnesium was comparable for case and control women, as were the intervals from beginning and termination of treatment to delivery. Adjustment for gestational age, birth weight, and other variables did not alter this result. CONCLUSION: Magnesium exposure was not associated with a lower risk of cerebral palsy in infants born prematurely to women without preeclampsia. The difference between this finding and that in our previous study showing an apparent neuroprotective effect of magnesium is not explained by the more restrictive selection criteria used here and may be related to a number of changes in medical practice between the 2 periods.
Authors:
J K Grether; J Hoogstrate; E Walsh-Greene; K B Nelson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  183     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-10     Completed Date:  2000-10-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  717-25     Citation Subset:  AIM; IM    
Affiliation:
March of Dimes Birth Defects Foundation/California Department of Health Services, California Birth Defects Monitoring Program, Auckland, CA 94606, USA.
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MeSH Terms
Descriptor/Qualifier:
Birth Weight
Case-Control Studies
Cerebral Palsy / epidemiology*,  prevention & control
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature*
Logistic Models
Magnesium Sulfate / therapeutic use*
Pre-Eclampsia*
Pregnancy
Retrospective Studies
Risk Factors
Tocolysis*
Grant Support
ID/Acronym/Agency:
NS35573-01/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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