Document Detail

Magnesium sulfate tocolysis and pulmonary edema: the drug or the vehicle?
MedLine Citation:
PMID:  15902128     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study was undertaken to determine the: (1) risk factors for developing pulmonary edema associated with magnesium sulfate (MgSO4) tocolysis; (2) mean latency period to diagnosis; (3) role of maternal transport; and (4) safety of continued therapy. STUDY DESIGN: A total of 150 antenatal patients treated for preterm labor with MgSO4 were identified for this retrospective, case-control study. Cases were compared 1:2 with controls in regard to maternal demographics, MgSO4 concentration and infusion rates, maternal transport status, and maternal net fluid balance. RESULTS: Risk factors for developing pulmonary edema include: greater MgSO4 and intravenous fluid infusion rates, less concentrated MgSO4, infection, multiple gestations, concomitant tocolytics, large positive net fluid balances, and maternal transport. The mean latency period to diagnosis was 1.96 days. Six percent of patients had recurrence if MgSO4 tocolysis was continued. CONCLUSIONS: MgSO4 and intravenous fluid rates are both associated with the development of pulmonary edema. Once appropriately treated, MgSO4 tocolysis can be continued with little risk of recurrence.
John M Samol; Donna S Lambers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  192     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-19     Completed Date:  2005-06-24     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1430-2     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Good Samaritan Hospital, Cincinnati, Ohio, USA.
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MeSH Terms
Biological Transport
Case-Control Studies
Infusions, Intravenous
Magnesium Sulfate / administration & dosage,  adverse effects*,  therapeutic use
Obstetric Labor, Premature / drug therapy
Osmolar Concentration
Pregnancy / metabolism
Pulmonary Edema / chemically induced*
Retrospective Studies
Time Factors
Tocolytic Agents / administration & dosage,  adverse effects*,  therapeutic use
Reg. No./Substance:
0/Tocolytic Agents; 7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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