| Magnesium sulfate potentiates several cardiovascular and metabolic actions of terbutaline. | |
MedLine Citation:
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PMID: 8131528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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beta-Adrenergic agonists are useful for the emergency treatment of asthma. Recently, magnesium sulfate (MgSO4) has also been shown to be efficacious in this situation. beta-Agonists have unwanted cardiovascular and metabolic actions: increased systolic blood pressure, corrected QT interval (QTc), serum glucose and insulin, and decreased RR interval, diastolic blood pressure, serum potassium, phosphate, and calcium. As beta-agonists and MgSO4 quite possibly will be used in combination, we sought to determine how MgSO4 would affect these actions. Healthy young male adults were administered two doses of terbutaline sulfate, 0.25 mg subcutaneously, 30 min apart on two separate occasions, in a randomized, double-blind fashion. On one occasion, 4 g of MgSO4 was administered intravenously over the same 30-min period. On the other, normal saline solution was given as a placebo. Cardiovascular and metabolic variables were measured sequentially for 2 h. Data at 60 min with p values given for a summation of all time points are as follows: MgSO4 increased terbutaline's effects on the RR interval by 0.09 s, p < 0.0001; QTc interval by 0.01 s, p < 0.0007; diastolic blood pressure by 8 mm Hg, p = 0.0001; serum calcium by 0.13 mg/dl, p = 0.01; and glucose by 9 mg/dl, p < 0.0001. MgSO4 also mitigated the systolic blood pressure elevating the effect of terbutaline by 5 mm Hg (p = 0.007). The magnitude of the response potentiations was modest. We conclude that combining terbutaline and MgSO4 is unlikely to result in serious short-term adverse events, if used acutely in patients with relatively normal cardiac and metabolic function. MgSO4 may act by potentiating the effect of beta-agonists on magnesium requiring enzymes such as adenyl cyclase. |
Authors:
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M S Skorodin; P C Freebeck; B Yetter; J E Nelson; W B Van de Graaff; J M Walsh |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Chest Volume: 105 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1994 Mar |
Date Detail:
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Created Date: 1994-04-15 Completed Date: 1994-04-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 701-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Veterans Affairs, Edward Hines Jr Hospital, Hines, Ill. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / drug effects Calcium / blood Double-Blind Method Drug Synergism Drug Therapy, Combination Hemodynamics / drug effects* Humans Magnesium / blood Magnesium Sulfate / pharmacology* Male Phosphates / blood Potassium / blood Terbutaline / pharmacology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Phosphates; 23031-25-6/Terbutaline; 7439-95-4/Magnesium; 7440-09-7/Potassium; 7440-70-2/Calcium; 7487-88-9/Magnesium Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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