Document Detail

Magnesium sulfate and cerebral palsy in premature infants.
MedLine Citation:
PMID:  9608889     Owner:  NLM     Status:  MEDLINE    
This article reviews clinical and experimental evidence as to whether magnesium sulfate, administered soon before premature birth, can reduce the high rate of cerebral palsy in tiny infants. Three observational studies have reported an association of magnesium sulfate with lower rate of cerebral palsy, whether treatment was for maternal preeclampsia or for tocolysis. One of these studies also noted a significant reduction in cognitive disability. In another study, no significant protective effect was seen except in a small subset of infants. Magnesium was neuroprotective in many but not all of a variety of experimental studies and has a variety of biologic effects that might account for benefit. All existing clinical studies had relatively small numbers of very premature infants. Although all attempted to control for possible confounders, such studies cannot provide definitive answers as to possible benefits or risks of magnesium therapy. Only randomized clinical trials are likely to resolve the question of whether a brief exposure to an agent which, in the American experience, is considered safe if administered with appropriate supervision, can reduce longterm neurologic disability in premature infants.
D G Hirtz; K Nelson
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in pediatrics     Volume:  10     ISSN:  1040-8703     ISO Abbreviation:  Curr. Opin. Pediatr.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-07-22     Completed Date:  1998-07-22     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9000850     Medline TA:  Curr Opin Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  131-7     Citation Subset:  IM    
National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
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MeSH Terms
Cerebral Palsy / physiopathology,  prevention & control*
Cerebrovascular Circulation / drug effects
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / prevention & control*
Magnesium Sulfate / pharmacology,  therapeutic use*
Tocolytic Agents / pharmacology,  therapeutic use*
Reg. No./Substance:
0/Tocolytic Agents; 7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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