| Magnesium status and parameters of the oxidant-antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. | |
| | |
MedLine Citation:
|
PMID: 10872900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Magnesium deficiency and oxidative stress have both been identified as pathogenic factors in aging and in several age-related diseases. The link between these two factors is unclear in humans although, in experimental animals, severe Mg deficiency has been shown to lead to increased oxidative stress. METHODS: The relationship between Mg body stores, dietary intakes and supplements on the one hand and parameters of the oxidant-antioxidant balance on the other was investigated in human subjects. RESULTS: The study population consisted of 93 patients with unexplained chronic fatigue (median age 38 years, 25% male, 16% smokers and 54% with Chronic Fatigue Syndrome (CFS). Mg deficient patients (47%) had lower total antioxidant capacity in plasma (p=0.007) which was related to serum albumin. Mg deficient patients whose Mg body stores did not improve after oral supplementation with Mg (10 mg/kg/day) had persistently lower blood glutathione levels (p=0.003). In vitro production of thiobarbituric acid reactive substances (TBARS) by non-HDL lipoproteins incubated with copper was related to serum cholesterol (p<0.001) but not to Mg or antioxidants and did not improve after Mg supplementation. In contrast, velocity of formation of fluorescent products of peroxidation (slope) correlated with serum vitamin E (p<0.001), which was, in turn, related to Mg dietary intakes. Both slope and serum vitamin E improved after Mg supplementation (p<0.001). CONCLUSIONS: These results show that the lower antioxidant capacity found in moderate Mg deficiency was not due to a deficit in Mg dietary intakes and was not accompanied by increased lipid susceptibility to in vitro peroxidation. Nevertheless, Mg supplementation was followed by an improvement in Mg body stores, in serum vitamin E and its interrelated stage of lipid peroxidation. |
| | |
Authors:
|
B Manuel y Keenoy; G Moorkens; J Vertommen; M Noe; J Nève; I De Leeuw |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of the American College of Nutrition Volume: 19 ISSN: 0731-5724 ISO Abbreviation: J Am Coll Nutr Publication Date: 2000 Jun |
Date Detail:
|
Created Date: 2000-10-11 Completed Date: 2001-01-25 Revised Date: 2008-06-23 |
Medline Journal Info:
|
Nlm Unique ID: 8215879 Medline TA: J Am Coll Nutr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 374-82 Citation Subset: IM |
Affiliation:
|
Laboratory of Endocrinology, University of Antwerp, Belgium. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aging Antioxidants / metabolism Dietary Supplements* Fatigue Syndrome, Chronic / drug therapy* Female Humans Infusions, Intravenous Lipid Metabolism Magnesium / administration & dosage*, metabolism, therapeutic use Magnesium Deficiency / complications, drug therapy* Male Middle Aged Oxidation-Reduction Oxidative Stress* Vitamin E / blood |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 1406-18-4/Vitamin E; 7439-95-4/Magnesium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Lactoferrin levels in term and preterm milk.
Next Document: Fasting lipoprotein and postprandial triacylglycerol responses to a low-carbohydrate diet supplement...