Document Detail

Magnesium modifies fentanyl-induced local antinociception and hyperalgesia.
MedLine Citation:
PMID:  19697012     Owner:  NLM     Status:  MEDLINE    
Fentanyl-induced hyperalgesia and antinociception after systemic administration has been shown in previous clinical and experimental studies. However, there is very little evidence regarding the local possible effects of fentanyl. The purpose of this study was to assess whether local (intraplantar) fentanyl administration can produce antinociception and hyperalgesia. In addition, we examined the effects of magnesium, N-methyl-D-aspartate receptor antagonist, on possible changes produced by fentanyl. The paw withdrawal latencies to radiant heat stimuli were measured to assess the thermal nociceptive actions. Intraplantar administration of fentanyl caused time and dose-dependent increase in the paw withdrawal latencies (antinociception). Coinjection of magnesium with fentanyl markedly enhanced the antinociception. However, fentanyl also markedly decreased paw withdrawal latencies 24 h after intraplantar administration (hyperalgesia). In the presence of magnesium, hyperalgesia after fentanyl administration was not observed. Consequently, following the fentanyl administration, local hyperalgesia after antinociception is a negative effect in pain treatment. Magnesium may not only prevent the hyperalgesia but also enhance antinociceptive effect of fentanyl.
Tufan Mert; Yasemin Gunes; Dilek Ozcengiz; Ismail Gunay
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-21
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  380     ISSN:  1432-1912     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2009-12-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  415-20     Citation Subset:  IM    
Department of Biophysics, Faculty of Medicine, Cukurova University, 01330 Balcali, Adana, Turkey.
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MeSH Terms
Analgesics, Opioid / pharmacology*,  toxicity
Drug Interactions
Drug Synergism
Fentanyl / pharmacology*,  toxicity
Hot Temperature
Hyperalgesia / chemically induced,  prevention & control
Magnesium / pharmacology*
Pain / drug therapy*
Pain Measurement
Rats, Wistar
Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
Reg. No./Substance:
0/Analgesics, Opioid; 0/Receptors, N-Methyl-D-Aspartate; 437-38-7/Fentanyl; 7439-95-4/Magnesium

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