| Magnesium ions and ionic channels: activation, inhibition or block--a hypothesis. | |
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MedLine Citation:
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PMID: 18062584 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The interactions between magnesium ions and ionic membrane channels are complicated and may be classified in three categories: activation, reduction and inhibition of the ionic fluxes across the channels, corresponding to three mechanisms: open-block-close. The interactions between magnesium ions and various ionic channels are reviewed and the explanations of the three mechanisms are analyzed in term of screening/binding effects on the membrane surface polar head groups. |
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Authors:
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Andrée Guiet-Bara; Jean Durlach; Michel Bara |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Magnesium research : official organ of the International Society for the Development of Research on Magnesium Volume: 20 ISSN: 0953-1424 ISO Abbreviation: Magnes Res Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-12-07 Completed Date: 2008-01-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900948 Medline TA: Magnes Res Country: England |
Other Details:
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Languages: eng Pagination: 100-6 Citation Subset: IM |
Affiliation:
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Laboratory of Physiology and Physiopathology, University P.M. Curie-Paris VI, Paris, France |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane Permeability / drug effects Humans Ion Channels / agonists, antagonists & inhibitors, physiology* Ion Transport / drug effects Magnesium / metabolism*, pharmacology Models, Biological |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels; 7439-95-4/Magnesium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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