| Magnesium infusion reduces the incidence of arrhythmias in acute myocardial infarction. A double-blind placebo-controlled study. | |
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MedLine Citation:
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PMID: 3297445 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a double-blind placebo-controlled study, 130 patients with verified acute myocardial infarction were given magnesium or placebo treatment intravenously immediately upon admission to hospital. The incidence of arrhythmias requiring treatment during the initial week of hospitalization was registered. Serum magnesium concentrations were increased from 0.7 mmol/l to 1.3 mmol/l as a result of the magnesium infusions. This pharmacologically induced hypermagnesemia resulted in a reduction in the incidence of arrhythmias from 47% in the placebo group to 21% in the magnesium group (p = 0.003). In the magnesium-treated patients, increments in serum concentrations of magnesium and potassium correlated positively (r = 0.47, p less than 0.001). It is concluded that magnesium infusion in the postinfarct period reduces the incidence of supraventricular tachyarrhythmias, and possible pathophysiological mechanisms involved are discussed. |
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Authors:
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H S Rasmussen; M Suenson; P McNair; P Nørregård; S Balslev |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical cardiology Volume: 10 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1987 Jun |
Date Detail:
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Created Date: 1987-08-04 Completed Date: 1987-08-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 351-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arrhythmias, Cardiac / etiology, prevention & control* Clinical Trials as Topic Double-Blind Method Female Humans Magnesium / blood, therapeutic use* Male Middle Aged Myocardial Infarction / complications, drug therapy* Potassium / blood Random Allocation |
| Chemical | |
Reg. No./Substance:
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7439-95-4/Magnesium; 7440-09-7/Potassium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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