Document Detail

Magnesium infusion reduces the incidence of arrhythmias in acute myocardial infarction. A double-blind placebo-controlled study.
MedLine Citation:
PMID:  3297445     Owner:  NLM     Status:  MEDLINE    
In a double-blind placebo-controlled study, 130 patients with verified acute myocardial infarction were given magnesium or placebo treatment intravenously immediately upon admission to hospital. The incidence of arrhythmias requiring treatment during the initial week of hospitalization was registered. Serum magnesium concentrations were increased from 0.7 mmol/l to 1.3 mmol/l as a result of the magnesium infusions. This pharmacologically induced hypermagnesemia resulted in a reduction in the incidence of arrhythmias from 47% in the placebo group to 21% in the magnesium group (p = 0.003). In the magnesium-treated patients, increments in serum concentrations of magnesium and potassium correlated positively (r = 0.47, p less than 0.001). It is concluded that magnesium infusion in the postinfarct period reduces the incidence of supraventricular tachyarrhythmias, and possible pathophysiological mechanisms involved are discussed.
H S Rasmussen; M Suenson; P McNair; P Nørregård; S Balslev
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical cardiology     Volume:  10     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-08-04     Completed Date:  1987-08-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  351-6     Citation Subset:  IM    
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MeSH Terms
Arrhythmias, Cardiac / etiology,  prevention & control*
Clinical Trials as Topic
Double-Blind Method
Magnesium / blood,  therapeutic use*
Middle Aged
Myocardial Infarction / complications,  drug therapy*
Potassium / blood
Random Allocation
Reg. No./Substance:
7439-95-4/Magnesium; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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