| Magnesium, inflammation, and obesity in chronic disease. | |
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MedLine Citation:
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PMID: 20536778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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About 60% of adults in the United States do not consume the estimated average requirement for magnesium, but widespread pathological conditions attributed to magnesium deficiency have not been reported. Nevertheless, low magnesium status has been associated with numerous pathological conditions characterized as having a chronic inflammatory stress component. In humans, deficient magnesium intakes are mostly marginal to moderate (approximately 50% to <100% of the recommended dietary allowance). Animal experiments indicate that signs of marginal-to-moderate magnesium deficiency can be compensated or exacerbated by other factors influencing inflammatory and oxidative stress; recent studies suggest a similar happening in humans. This suggestion may have significance in obesity, which is characterized as having a chronic low-grade inflammation component and an increased incidence of a low magnesium status. Marginal-to-moderate magnesium deficiency through exacerbating chronic inflammatory stress may be contributing significantly to the occurrence of chronic diseases such as atherosclerosis, hypertension, osteoporosis, diabetes mellitus, and cancer. |
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Authors:
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Forrest H Nielsen |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Nutrition reviews Volume: 68 ISSN: 1753-4887 ISO Abbreviation: Nutr. Rev. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
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Languages: eng Pagination: 333-40 Citation Subset: IM |
Affiliation:
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US Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202-9034, USA. forrest.nielsen@ars.usda.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chronic Disease Humans Inflammation / complications, physiopathology* Magnesium / administration & dosage, physiology* Magnesium Deficiency / complications Nutritional Status* Obesity / complications, physiopathology* |
| Chemical | |
Reg. No./Substance:
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7439-95-4/Magnesium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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