Document Detail


Magnesium in the prevention of lethal arrhythmias in acute myocardial infarction.
MedLine Citation:
PMID:  3548627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seven of 48 patients (14.6%) with acute myocardial infarction who were given 2.4 g of magnesium sulfate as a single intravenous dose had potentially lethal arrhythmias during the first 24 hours after admission, whereas 16 (34.8%) of 46 patients receiving placebo had similar arrhythmias. In addition, 14 of these 16 patients in the placebo group had their first arrhythmia (in the intensive coronary-care unit) within two hours after the start of the study, whereas in the magnesium-treated group, there were no such arrhythmias until some four hours later. The higher the lymphocyte potassium concentration, the greater the reduction in the incidence of arrhythmias. Serum magnesium levels increased by 16.5% and lymphocyte magnesium concentrations by 72% in the magnesium treated group. Intravenous magnesium reduces the incidence of serious arrhythmias after acute myocardial infarction.
Authors:
A S Abraham; D Rosenmann; M Kramer; J Balkin; M M Zion; H Farbstien; U Eylath
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Archives of internal medicine     Volume:  147     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-04-22     Completed Date:  1987-04-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  753-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Arrhythmias, Cardiac / blood,  prevention & control*
Blood Urea Nitrogen
Clinical Trials as Topic
Double-Blind Method
Female
Humans
Lymphocytes / metabolism
Magnesium / adverse effects,  blood,  therapeutic use*
Male
Middle Aged
Myocardial Infarction / blood,  complications,  drug therapy*
Potassium / blood
Prospective Studies
Random Allocation
Chemical
Reg. No./Substance:
7439-95-4/Magnesium; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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