Document Detail


Magnesium and diltiazem relaxes phenylephrine-precontracted rat aortic rings.
MedLine Citation:
PMID:  22523136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Perioperative vasospasm during cardiovascular surgery is a challenging problem. Several vasodilator agents are frequently utilized for its prevention in surgical practice. Magnesium and diltiazem both have known potential vasorelaxant effects. We planned to compare the efficacy of diltiazem and magnesium in relieving phenylephrine-precontracted rat aortic rings. Ten young adult female Wistar albino rats weighing 230-260 g were used in this study. The aortic rings in the organ bath equilibrated and reached their baseline tension. Precontraction was induced by 0.001 mmol/l phenylephrine and cumulative concentration-relaxation curves were obtained by consecutively increasing the addition of either diltiazem (10(-6)-0.1 mmol/l) or magnesium (0.1-10 mmol/l). The mean maximal relaxation responses observed by diltiazem and magnesium on separate aortic rings were 90 ± 3 and 53 ± 2%, respectively. The calculated EC50 of diltiazem was 0.01035 mmol/l, whereas the EC50 of magnesium was 4.064 mmol/l (P < 0.05). Both magnesium and diltiazem produced vasorelaxation on phenylephrine-precontracted rat aortic rings in this study, but the potency of diltiazem regarding the EC50 value was significantly higher than that of magnesium. Magnesium could be a candidate together with diltiazem to inhibit vasospasm on arterial grafts during coronary bypass surgery.
Authors:
Mustafa Dogan; Recep O Peker; Soner Donmez; Osman Gokalp
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article     Date:  2012-04-21
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  15     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-22     Completed Date:  2012-10-29     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Affiliation:
Diabetes Research Group, King's College, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Thoracic / drug effects*
Diltiazem / pharmacology*
Dose-Response Relationship, Drug
Female
Magnesium Sulfate / pharmacology*
Phenylephrine / pharmacology*
Rats
Rats, Wistar
Vasoconstriction / drug effects*
Vasoconstrictor Agents / pharmacology*
Vasodilation / drug effects*
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 0/Vasodilator Agents; 42399-41-7/Diltiazem; 59-42-7/Phenylephrine; 7487-88-9/Magnesium Sulfate
Comments/Corrections

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