| Magnesium dietary manipulation and recovery of function following controlled cortical damage in the rat. | |
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MedLine Citation:
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PMID: 18557131 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous research has shown that dietary magnesium (Mg2+) deficiency prior to injury worsens recovery of function and that systemic administration of Mg2+ pre or post-injury significantly improves functional recovery. The purpose of the present study was to determine if manipulations in dietary Mg2+ would alter functional recovery following unilateral cortical injuries. Two weeks prior to injury, rats were placed on a customized diet enriched with Mg2+, deficient in Mg2+, or on a standard Mg2+ diet. Rats were then prepared with unilateral cortical contusion injuries (CCI) of the sensorimotor cortex. Two days following CCI, rats were tested on a battery of sensorimotor (vibrissae-forelimb placing and bilateral tactile adhesive removal tests), as well as the acquisition of reference memory in the Morris water maze. Serum analysis for Mg2+ prior to injury showed a diet-dependent modulation in levels. The Mg(2+)-enriched diet showed significantly higher levels of serum Mg2+ compared to the normal diet and the Mg(2+)-deficient diet showed significantly lower levels compared to the Mg(2+)-normal diet. On the placing and tactile removal tests Mg2+ deficiency significantly worsened recovery compared to the Mg(2+)-enriched and Mg(2+-)normal diet conditions. There were no statistically significant differences between the Mg(2+)-normal and Mg(2+)-enriched diets on the sensorimotor tests. On the acquisition of reference memory there were no significant difference between diet conditions; however, the Mg(2+)-deficient diet showed a trend toward impaired performance compared to the other diet conditions. The Mg(2+)-deficient diet resulted in a larger lesion cavity compared to the other diet conditions. These findings suggest that dietary Mg2+ modulates recovery of function. |
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Authors:
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Michael R Hoane; David R Gilbert; Adrianne B Barbre; Stacy A Harrison |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Magnesium research : official organ of the International Society for the Development of Research on Magnesium Volume: 21 ISSN: 0953-1424 ISO Abbreviation: Magnes Res Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-06-17 Completed Date: 2008-07-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8900948 Medline TA: Magnes Res Country: England |
Other Details:
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Languages: eng Pagination: 29-37 Citation Subset: IM |
Affiliation:
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Restorative Neuroscience Laboratory, Brain and Cognitive Science Program, Department of Psychology, Southern Illinois University, Carbondale, IL 62901, USA. mhoane@siu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Injuries / diet therapy, physiopathology, prevention & control* Dietary Supplements Magnesium / administration & dosage, blood, pharmacology* Male Maze Learning / drug effects Motor Activity / drug effects Psychomotor Performance / drug effects Rats Rats, Sprague-Dawley Recovery of Function / drug effects* |
| Chemical | |
Reg. No./Substance:
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7439-95-4/Magnesium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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