Document Detail


Magnesium deficiency and cardiac disorders.
MedLine Citation:
PMID:  806229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Magnesium deficiency can occur in congestive heart failure, after diuresis with furoxemide, ethacrynic acid and mercurials, and with digitalis intoxication, diabetic acidosis, acute and chronic alcoholism, delerium tremens, cirrhosis, malabsorption syndromes, protracted postoperative cases, open heart surgery, the diuretic phase of acute tubular necrosis, and with hypoparathyroidism, primary aldosteronism, juxta-glomerular hyperplasia and pancreatitis. Two cases of serious ventricular arrhythmias associated with magnesium depletion are described. Clinical manifestations are vague but center around neurologic symptoms such as weakness, tremors, stupor, coma, nausea, vomiting and anorexia. Serious cardiac arrhythmias also occur with magnesium depletion. Magnesium appears to be very useful in hypomagnesemic or digitalis-toxic tachyarrhythmias. Magnesium may also be valuable in normomagnesemic tachyarrhythmias. Ten to fifteen milliliters of a 20 percent magnesium sulfate solution, given intravenously over 1 minute, followed by a slow 4 to 6 hour infusion of 500 ml of 2 per cent magnesium sulfate in 5 per cent dextrose in water is recommended. Recurrence of arrhythmias is common and a second infusion of magnesium sulfate may be necessary. Hypermagnesemia occurs frequently in renal insufficiency, and magnesium therapy may then be contraindicated. Serum levels above 5.5 meq/liter should be avoided. Loss of deep tendon reflexes and a decrease in respiratory rate can be used as guides to magnesium therapy. A plea is made for frequent analysis of serum magnesium so that more knowledge can be gained regarding this important biologic element in cardiovascular disorders.
Authors:
L T Iseri; J Freed; A R Bures
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  58     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-09-09     Completed Date:  1975-09-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  837-46     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Alcoholism / complications
Arrhythmias, Cardiac / chemically induced,  etiology*
Diabetic Ketoacidosis / complications
Digitalis Glycosides / adverse effects
Female
Heart Failure / complications*
Humans
Hyperaldosteronism / complications*
Hypoparathyroidism / complications
Kidney Tubular Necrosis, Acute / complications
Liver Cirrhosis / complications
Magnesium / administration & dosage,  adverse effects,  therapeutic use
Magnesium Deficiency / complications*,  diagnosis,  etiology
Malabsorption Syndromes / complications
Male
Middle Aged
Pancreatitis / complications
Postoperative Complications
Chemical
Reg. No./Substance:
0/Digitalis Glycosides; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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