Document Detail

Magnesium deficiency and cardiac disorders.
MedLine Citation:
PMID:  806229     Owner:  NLM     Status:  MEDLINE    
Magnesium deficiency can occur in congestive heart failure, after diuresis with furoxemide, ethacrynic acid and mercurials, and with digitalis intoxication, diabetic acidosis, acute and chronic alcoholism, delerium tremens, cirrhosis, malabsorption syndromes, protracted postoperative cases, open heart surgery, the diuretic phase of acute tubular necrosis, and with hypoparathyroidism, primary aldosteronism, juxta-glomerular hyperplasia and pancreatitis. Two cases of serious ventricular arrhythmias associated with magnesium depletion are described. Clinical manifestations are vague but center around neurologic symptoms such as weakness, tremors, stupor, coma, nausea, vomiting and anorexia. Serious cardiac arrhythmias also occur with magnesium depletion. Magnesium appears to be very useful in hypomagnesemic or digitalis-toxic tachyarrhythmias. Magnesium may also be valuable in normomagnesemic tachyarrhythmias. Ten to fifteen milliliters of a 20 percent magnesium sulfate solution, given intravenously over 1 minute, followed by a slow 4 to 6 hour infusion of 500 ml of 2 per cent magnesium sulfate in 5 per cent dextrose in water is recommended. Recurrence of arrhythmias is common and a second infusion of magnesium sulfate may be necessary. Hypermagnesemia occurs frequently in renal insufficiency, and magnesium therapy may then be contraindicated. Serum levels above 5.5 meq/liter should be avoided. Loss of deep tendon reflexes and a decrease in respiratory rate can be used as guides to magnesium therapy. A plea is made for frequent analysis of serum magnesium so that more knowledge can be gained regarding this important biologic element in cardiovascular disorders.
L T Iseri; J Freed; A R Bures
Related Documents :
3060319 - Lymphocytic angiitis following streptokinase therapy.
6692439 - Intraarterial infusion of low-dose streptokinase after acute thromboembolization of the...
3488129 - Late thrombolysis with intracoronary streptokinase after myocardial infarction.
16144179 - Bilateral upper extremity thrombophlebitis related to intravenous amiodarone: a case re...
12639869 - Serum magnesium aberrations in furosemide (frusemide) treated patients with congestive ...
7198469 - Reperfusion effects on the magnesium-procaine arrested rabbit heart.
18951929 - Attenuation of edema and infarct volume following focal cerebral ischemia by early but ...
22748279 - The impact of admission red cell distribution width on the development of poor myocardi...
6991109 - Role of echocardiographic studies in the ambulatory patient.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  58     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-09-09     Completed Date:  1975-09-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  837-46     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alcoholism / complications
Arrhythmias, Cardiac / chemically induced,  etiology*
Diabetic Ketoacidosis / complications
Digitalis Glycosides / adverse effects
Heart Failure / complications*
Hyperaldosteronism / complications*
Hypoparathyroidism / complications
Kidney Tubular Necrosis, Acute / complications
Liver Cirrhosis / complications
Magnesium / administration & dosage,  adverse effects,  therapeutic use
Magnesium Deficiency / complications*,  diagnosis,  etiology
Malabsorption Syndromes / complications
Middle Aged
Pancreatitis / complications
Postoperative Complications
Reg. No./Substance:
0/Digitalis Glycosides; 7439-95-4/Magnesium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Serologic characterization of patients with two episodes of acute viral hepatitis.
Next Document:  Varied manifestations of a familial lymphoproliferative disorder.