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Maggot Therapy for Wound Debridement: A Randomized Multicenter Trial.
MedLine Citation:
PMID:  22184720     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: To study the efficacy of bagged larvae on wound debridement compared with conventional treatment. DESIGN: Randomized, multicenter, controlled, prospective phase 3 trial with blinded assessment of outcome measures by a single observer. SETTING: Two hospital referral centers in Caen and Lyon, France. Patients  Random sampling of 119 patients with a nonhealing, sloughy wound 40 cm(2) or smaller, less than 2 cm deep, and an ankle brachial index of 0.8 or higher. Intervention  During a 2-week hospital stay, patients received either maggot debridement therapy (MDT) or conventional treatment. At discharge, conventional dressings were applied and a follow-up visit occurred at day 30. Main Outcome Measure  Percentage of slough in wounds at day 15. RESULTS: There was a significant difference between groups at day 8 (54.5% in the MDT group and 66.5% in the control group) (P = .04). The mean percentage of slough at day 15 was 55.4% in the MDT group and 53.8% in the control group (P = .78). CONCLUSIONS: Although MDT shows no significant benefit at day 15 compared with conventional treatment, debridement by MDT is significantly faster and occurs during the first week of treatment. Because there is no benefit in continuing the treatment after 1 week, another type of dressing should be used after 2 or 3 applications of MDT. Trial Registration  clinicaltrials.gov Identifier: NCT01211236.
Authors:
Kristina Opletalová; Xavier Blaizot; Bénédicte Mourgeon; Yannick Chêne; Christian Creveuil; Patrick Combemale; Anne-Laure Laplaud; Ingrid Sohyer-Lebreuilly; Anne Dompmartin
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-19
Journal Detail:
Title:  Archives of dermatology     Volume:  -     ISSN:  1538-3652     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Laplaud, Sohyer-Lebreuilly, and Dompmartin and Ms Mourgeon), and Biostatistics and Clinical Research Unit, Clinical and Epidemiological Research Department (Drs Blaizot and Creveuil and Mr Chêne), Université de Caen Basse-Normandie, Centre Hospitalier Universitaire de Caen, Caen, France; and Department of Dermatology, Hôpital Desgenettes, and Regional Center Léon Bérard, Lyon, France (Dr Combemale).
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