| Maduropeptin, a complex of new macromolecular antitumor antibiotics. | |
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MedLine Citation:
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PMID: 2032949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maduropeptin, a complex of new macromolecular antitumor antibiotics, is a metabolite of Actinomadura madurae H710-49. The active components maduropeptins A1, A2 and B are acidic chromopeptides with MW of around 22,500 and composed of 14 types of amino acids and an unstable chromophore. The antibiotics are active in vitro against Gram-positive bacteria and highly cytotoxic to tumor cells. They produced significant prolongation of survival time of mice implanted with P388 leukemia and B16 melanoma. |
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Authors:
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M Hanada; H Ohkuma; T Yonemoto; K Tomita; M Ohbayashi; H Kamei; T Miyaki; M Konishi; H Kawaguchi; S Forenza |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of antibiotics Volume: 44 ISSN: 0021-8820 ISO Abbreviation: J. Antibiot. Publication Date: 1991 Apr |
Date Detail:
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Created Date: 1991-06-26 Completed Date: 1991-06-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0151115 Medline TA: J Antibiot (Tokyo) Country: JAPAN |
Other Details:
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Languages: eng Pagination: 403-14 Citation Subset: IM |
Affiliation:
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Bristol-Myers Squibb Research Institute, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actinomyces
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metabolism Amino Acids / analysis Animals Anti-Bacterial Agents* Antibiotics, Antineoplastic / biosynthesis, chemistry, therapeutic use* Chromatography, High Pressure Liquid Drug Stability Enediynes Female Gram-Positive Bacteria / drug effects Leukemia P388 / drug therapy Male Melanoma, Experimental / drug therapy Mice Molecular Weight Peptide Biosynthesis Peptides / chemistry, therapeutic use Photochemistry |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Anti-Bacterial Agents; 0/Antibiotics, Antineoplastic; 0/Enediynes; 0/Peptides; 134910-70-6/maduropeptin A1; 134910-71-7/maduropeptin A2; 134910-72-8/maduropeptin B; 134910-73-9/maduropeptin C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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