Document Detail

Macular pigmentary changes as a sequelae of retinal hemorrhages in premature infants with retinopathy of prematurity.
MedLine Citation:
PMID:  16310326     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We assess the incidence of macular changes in ROP patients with retinal hemorrhages. PATIENTS AND METHODS: The premature group consisted of 360 children born 32 weeks gestation and/or with weight below 1,500 g. We used the RetCam-120 Digital Retinal Camera to document retinal changes. RESULTS: Of the 360 premature infants 241 (67%) had no ROP, and 119 (33%) had ROP. Of the preterm infants with ROP retinal hemorrhages were found in 46 (38%) children. Of the newborns with ROP and with retinal hemorrhages, macular pigmentary changes were found in 3 (6%) patients. Of these 3 patients, the first had pre-threshold ROP, the second threshold ROP and had underwent diode laser photocoagulation, and the third patient had stage 2 ROP. In the patients with pre-threshold and threshold ROP retinal hemorrhages appeared 6 weeks after birth and macular pigmentary changes were found 6 months after birth. In the patient with stage 2 ROP hemorrhages appeared 7-8 weeks after birth and macular pigmentary changes were detected 12 months after birth. CONCLUSIONS: Although macular hemorrhages almost always resorb without complications, our study allows the assumption that retinal hemorrhages may cause macular pigmentary changes in the macula, and thus may lead to deprivation amblyopia. Our results may suggest that the presence of the macular pigmentary changes may be related to the hemorrhage and not to the specific therapy or to the disease.
Malgorzata Mrugacz; Regina Antosiuk; Grzegorz Mrugacz; Alina Bakunowicz-Łazarczyk
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Publication Detail:
Type:  Journal Article     Date:  2005-11-28
Journal Detail:
Title:  Early human development     Volume:  82     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-31     Completed Date:  2006-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  39-42     Citation Subset:  IM    
Department of Pediatric Ophthalmology, Medical University of Bialystok, 17 Washington Str., 15-274 Bialystok, Poland.
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MeSH Terms
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature*
Pigment Epithelium of Eye / pathology*
Poland / epidemiology
Retina / pathology*
Retinal Hemorrhage / complications*,  epidemiology,  pathology
Retinopathy of Prematurity / complications*,  epidemiology,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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