| MACULAR MICROPSEUDOCYSTS IN EARLY STAGES OF DIABETIC RETINOPATHY. | |
| | |
MedLine Citation:
|
PMID: 21394067 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
PURPOSE:: To identify by noninvasive means early retinal abnormalities that may predict diabetic macular edema. METHODS:: The authors analyzed retrospectively data from consecutive patients with Type 1 (n = 16) or Type 2 (n = 23) diabetes who presented for routine follow-up of early retinopathy, had no clinical signs or symptoms of diabetic macular edema, and were evaluated with spectral-domain optical coherence tomography. Age- and gender-matched nondiabetic subjects provided normative data. RESULTS:: Spectral-domain optical coherence tomography revealed in the macular region of diabetic patients small hyporeflective areas (median diameter, 55 μm) contained within discrete retinal layers that we named micropseudocysts (MPCs). Micropseudocysts are associated with vascular leakage. The patients showing MPCs had more frequently systemic hypertension and increased central foveal thickness than those without MPCs. The association with increased central foveal thickness was only in the patients with Type 2 diabetes. CONCLUSION:: Macular MPCs in patients with mild diabetic retinopathy appear to reflect leakage and can precede macular thickening. The association of MPCs with increased central foveal thickness in patients with Type 2 diabetes, but not in patients with Type 1 diabetes, points to a greater tendency to retinal fluid accumulation in patients with Type 2 diabetes. Studies in larger cohorts will determine the usefulness of MPCs in strategies to abort diabetic macular edema. |
| | |
Authors:
|
Gemma Tremolada; Luisa Pierro; Umberto De Benedetto; Sergio Margari; Marco Gagliardi; Gisella Maestranzi; Giliola Calori; Mara Lorenzi; Rosangela Lattanzio |
Related Documents
:
|
15811197 - Diabetic dyslipidaemia: insights for optimizing patient management. 7986307 - The contribution of lipids to coronary heart disease in diabetes mellitus. 20121887 - Friedewald equation underestimates low-density lipoprotein cholesterol at low concentra... 20557887 - Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals ... 17200317 - Epiphysiodesis with infusion of stromal cell-derived factor-1 in rabbit growth plates. 6762277 - Immunologic reactivity to insulin: animal models and clinical syndromes. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-09 |
Journal Detail:
|
Title: Retina (Philadelphia, Pa.) Volume: - ISSN: 1539-2864 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-11 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309919 Medline TA: Retina Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the *Department of Ophthalmology; †University Vita-Salute, Scientific Institute San Raffaele, Milan, Italy; ‡Epidemiology Unit, Scientific Institute San Raffaele, Milan, Italy; and §Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: MAINTAINING A WATERTIGHT GLOBE WHILE OPERATING WITH A TEMPORARY KERATOPROSTHESIS.
Next Document: COMPARATIVE IN VITRO SAFETY ANALYSIS OF DYES FOR CHROMOVITRECTOMY-INDOCYANINE GREEN, BRILLIANT BLUE ...