Document Detail

Macular microcirculation in hypertensive patients with and without branch retinal vein occlusion.
MedLine Citation:
PMID:  18631327     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Our purpose was to determine whether a reduction in blood flow velocity (BFV) in the perifoveal capillaries is involved in the pathogenesis of branch retinal vein occlusion (BRVO) in patients with hypertension. METHODS: Subjects included hypertensive patients with (n = 12) and without (n = 16) BRVO and healthy volunteers (n = 16). Perifoveal BFV was measured by the tracing method using fluorescein angiography and a scanning laser ophthalmoscope. Logistic regression analysis was performed to assess factors that influenced the presence or absence of BRVO. RESULTS: Mean BFV showed a significant decrease across the three groups (healthy controls: 1.49 +/- 0.11 mm/second; hypertensive patients without BRVO: 1.36 +/- 0.12 mm/second; hypertensive patients with BRVO: 1.16 +/- 0.24 mm/second; p(trend) < 0.001). Multivariate logistic regression analysis showed that BFV was a significant risk factor for the presence of BRVO. CONCLUSIONS: Perifoveal capillary BFV is reduced in hypertensive patients with and without BRVO. It is possible that a decrease in BFV may be involved in the occurrence of BRVO. Measurement of perifoveal capillary BFV may be useful for investigating the pathogenesis and progression of BRVO.
Hidetaka Noma; Hideharu Funatsu; Kumi Sakata; Seiyo Harino; Tatsuya Mimura; Sadao Hori
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Publication Detail:
Type:  Journal Article     Date:  2008-07-08
Journal Detail:
Title:  Acta ophthalmologica     Volume:  87     ISSN:  1755-3768     ISO Abbreviation:  -     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-01     Completed Date:  2009-11-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468102     Medline TA:  Acta Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  638-42     Citation Subset:  IM    
Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Tokyo, Japan.
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MeSH Terms
Blood Flow Velocity
Capillaries / physiopathology
Fluorescein Angiography
Fovea Centralis / blood supply
Hypertension / complications*,  physiopathology*
Logistic Models
Macula Lutea / blood supply*
Microscopy, Confocal
Middle Aged
Retinal Vein Occlusion / etiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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