Document Detail


Macular fibrosis in Coats disease.
MedLine Citation:
PMID:  20419849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The purpose of this study was to describe the angiographic features and visual impact of macular fibrosis in patients with Coats disease.
METHODS: This is a single institution retrospective case series. Charts of patients diagnosed with Coats disease between 1973 and 2007 were reviewed. Data collected included patient demographics, treatment method, initial and final logarithm of the minimum angle of resolution visual acuity, photographic findings, angiographic characteristics, and anatomical outcome.
RESULTS: Forty-seven patients were identified with adequate imaging and posttreatment follow-up. Average age at presentation was 38 years (4-82 years). Average follow-up was 4.9 years (0-17 years). Macular fibrosis was identified in 11 patients (23%). At presentation, the average logarithm of the minimum angle of resolution visual acuity was as follows: all patients, 0.67; patients with macular fibrosis, 1.14; and patients without macular fibrosis, 0.50 (P = 0.01, 2-tailed Student's t-test). The average posttreatment logarithm of the minimum angle of resolution visual acuity was as follows: all patients, 0.78; patients with macular fibrosis, 0.97; and patients without macular fibrosis, 0.70 (P = 0.26). Macular fibrosis was associated with a pigmented spot at the point of apparent intraretinal vascular anastamosis. Fluorescein angiography showed leakage consistent with neovascularization that appeared to be intraretinal.
CONCLUSION: Macular fibrosis is a common finding in Coats disease, occurring in 23% of our patients. It may be a result of intraretinal neovascularization and is associated with a worse vision outcome.
Authors:
J Michael Jumper; Dustin Pomerleau; H Richard McDonald; Robert N Johnson; Arthur D Fu; Emmett T Cunningham
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  30     ISSN:  1539-2864     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-06-11     Revised Date:  2011-12-02    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S9-14     Citation Subset:  IM    
Affiliation:
West Coast Retina Medical Group, San Francisco, California 94107, USA. JMJumper@WestCoastRetina.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Capillary Permeability
Child
Child, Preschool
Exudates and Transudates
Female
Fibrosis / diagnosis
Fluorescein Angiography
Follow-Up Studies
Humans
Macula Lutea / pathology*
Male
Middle Aged
Retinal Neovascularization / diagnosis*
Retinitis / diagnosis*
Retrospective Studies
Visual Acuity / physiology
Young Adult
Comments/Corrections
Comment In:
Retina. 2011 Nov;31(10):2136-7; author reply 2137-8   [PMID:  22027803 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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