| Macula densa sensing and signaling mechanisms of renin release. | |
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MedLine Citation:
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PMID: 20360309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Macula densa cells in the distal nephron, according to the classic paradigm, are salt sensors that generate paracrine chemical signals in the juxtaglomerular apparatus to control vital kidney functions, including renal blood flow, glomerular filtration, and renin release. Renin is the rate-limiting step in the activation of the renin-angiotensin system, a key modulator of body fluid homeostasis. Here, we discuss recent advances in understanding macula densa sensing and suggest these cells, in addition to salt, also sense various chemical and metabolic signals in the tubular environment that directly trigger renin release. |
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Authors:
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János Peti-Peterdi; Raymond C Harris |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-04-01 |
Journal Detail:
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Title: Journal of the American Society of Nephrology : JASN Volume: 21 ISSN: 1533-3450 ISO Abbreviation: J. Am. Soc. Nephrol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-07-21 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 9013836 Medline TA: J Am Soc Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 1093-6 Citation Subset: IM |
Affiliation:
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Departments of Physiology and Biophysics and Medicine, Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, California, USA. petipete@usc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glomerular Filtration Rate / physiology Homeostasis / physiology Humans Juxtaglomerular Apparatus / blood supply, physiology* Kidney Tubules, Distal / blood supply, physiology* Mice Mice, Knockout Models, Animal Nephrons / blood supply, physiology* Regional Blood Flow / physiology Renin / metabolism* Renin-Angiotensin System / physiology Signal Transduction / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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64324//PHS HHS; DK62795/DK/NIDDK NIH HHS; DK74754/DK/NIDDK NIH HHS; DK79341/DK/NIDDK NIH HHS; R01 DK064324-07/DK/NIDDK NIH HHS; R01 DK064324-08/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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