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Macrophages and neutrophils in SLE-An online molecular catalog.
MedLine Citation:
PMID:  22036828     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Systemic Lupus Erythematosus (SLE) is a heterogeneous group of autoimmune disorders defined by a consensus of clinical and laboratory criteria. Much of the pathophysiology and therapy of SLE has focused on autoimmune B and T cells of the adaptive immune system. Recently, focus has shifted to the role of myeloid cells like neutrophils and macrophages - part of the innate immune system - in SLE pathogenesis. These cells have altered molecular profiles affecting multiple pathways, but no salient overview has been undertaken to broadly define and categorize this dysregualtion. Here we endeavor to provide this overview and build a new freely accessible online resource for this purpose (http://www.mohanlab.org/SLE_BASE/myeloid_cells/).
Authors:
Jacob Orme; Chandra Mohan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-19
Journal Detail:
Title:  Autoimmunity reviews     Volume:  -     ISSN:  1873-0183     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101128967     Medline TA:  Autoimmun Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Published by Elsevier B.V.
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