| Macrophages on the nasal mucosal surface in provoked and naturally occurring allergic rhinitis. | |
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MedLine Citation:
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PMID: 1759583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Macrophages are the most common cell type residing in the lumen of the lower airways. However, very little is known about the presence and putative pathogenic implications of macrophages in the upper airways. Using specific immunohistochemical techniques, the presence of and changes in macrophage density were studied before and after allergen exposure in the laboratory and during natural allergen exposure of subjects with seasonal allergic rhinitis. The monoclonal antibody EBM 11 combined with the alkaline phosphatase-anti-alkaline phosphatase-technique was applied on cytospin-prepared slides. In the challenge experiment, 0.5 +/- 0.2% (mean +/- SEM; n = 10) of the total cell number were positive for the EBM 11 marker before challenge, thereby not differing from the controls (0.2 +/- 0.2%; mean +/- SEM; n = 3). Local allergen challenge induced an increase of these cells to a peak of 1.3 +/- 0.4% after 4 h (p less than 0.05). During seasonal exposure there was also a similar increase, from 0.7 +/- 0.2 to 1.3 +/- 0.3% (p less than 0.05; n = 11) in placebo-treated patients and from 0.7 +/- 0.2 to 1.6 +/- 0.4% (p less than 0.05; n = 11) in patients treated with topical glucocorticoids. There was, however, no direct relationship between nasal symptoms and number of macrophages present on the mucosal surface. The study indicates that macrophages are involved in the inflammatory processes of allergic rhinitis. |
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Authors:
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S Juliusson; C Bachert; H Klementsson; G Karlsson; U Pipkorn |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta oto-laryngologica Volume: 111 ISSN: 0001-6489 ISO Abbreviation: Acta Otolaryngol. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-02-03 Completed Date: 1992-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370354 Medline TA: Acta Otolaryngol Country: SWEDEN |
Other Details:
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Languages: eng Pagination: 946-53 Citation Subset: IM |
Affiliation:
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Department of Oto-Rhino-Laryngology, Sahlgren's Hospital, Gothenburg, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Allergens / administration & dosage Antibodies, Monoclonal / immunology Antigens, CD / immunology Antigens, Differentiation, Myelomonocytic / immunology Bronchial Provocation Tests Female Humans Immunoenzyme Techniques Leukocyte Count Macrophages Male Nasal Mucosa / immunology* Rhinitis, Allergic, Seasonal / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Antibodies, Monoclonal; 0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human |
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