| Macrophages discriminate glycosylation patterns of apoptotic cell-derived microparticles. | |
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MedLine Citation:
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PMID: 22074924 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Inappropriate clearance of apoptotic remnants is considered to be the primary cause of systemic autoimmune diseases, like systemic lupus erythematosus. Here we demonstrate that apoptotic cells release distinct types of subcellular membranous particle (scMP) derived from the endoplasmic reticulum (ER) or the plasma membrane. Both types of scMP exhibit desialylated glycotopes resulting from surface exposure of immature ER-derived glycoproteins or from surface-borne sialidase activity, respectively. Sialidase activity is activated by caspase-dependent mechanisms during apoptosis. Cleavage of sialidase Neu1 by caspase 3 was shown to be directly involved in apoptosis-related increase of surface sialidase activity. ER-derived blebs possess immature mannosidic glycoepitops and are prioritized by macrophages during clearance. Plasma membrane-derived blebs contain nuclear chromatin (DNA and histones) but not components of the nuclear envelope. Existence of two immunologically distinct types of apoptotic blebs may provide new insights into clearance-related diseases. |
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Authors:
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Rostyslav O Bilyy; Tanya Shkandina; Andriy Tomin; Luis E Munoz; Sandra Franz; Volodymyr Antonyuk; Yuriy Ya Kit; Matthias Zirngibl; Barbara G Fuernrohr; Christina Janko; Kirsten Lauber; Martin Schiller; Georg Schett; Rostyslav S Stoika; Martin Herrmann |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-10 |
Journal Detail:
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Title: The Journal of biological chemistry Volume: - ISSN: 1083-351X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985121R Medline TA: J Biol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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National Academy of Sciences of Ukraine, Ukraine; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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