| Macrophages contain 92-kd gelatinase (MMP-9) at the site of degenerated internal elastic lamina in temporal arteritis. | |
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MedLine Citation:
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PMID: 8909231 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammation precedes erosion and rupture of atherosclerotic atheromas and aneurysms. Inflammatory infiltrates of macrophages have been shown to secrete proteolytic enzymes, including matrix metalloproteinases (MMPs), that weaken the arterial wall. The effect of inflammation on arterial structure and remodeling can be studied in primary vascular inflammatory diseases such as in temporal arteritis. We examined the 72-kd gelatinase (MMP-2) and the 92-kd gelatinase (MMP-9) in inflamed and uninvolved temporal arteries from 10 patients with temporal arteritis and 5 controls by immunohistochemistry. The substrates of these enzymes, type IV collagen and elastin, were detected by immunohistochemistry and histochemical staining, respectively. Both diseased and normal artery specimens had moderate staining for immunoreactive MMP-2. Temporal arteritis specimens had clearly enhanced immunostaining for MMP-9 compared with normal arteries. MMP-9 was specifically localized to macrophages in regions of internal elastic lamina disruption, which may thus be of pathological significance. |
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Authors:
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S T Nikkari; M Höyhtyä; J Isola; T Nikkari |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of pathology Volume: 149 ISSN: 0002-9440 ISO Abbreviation: Am. J. Pathol. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1996-12-13 Completed Date: 1996-12-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0370502 Medline TA: Am J Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1427-33 Citation Subset: AIM; IM |
Affiliation:
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Department of Medical Biochemistry, University of Tampere Medical School, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Collagenases / analysis* Elastic Tissue / enzymology*, pathology* Female Gelatinases / analysis Giant Cell Arteritis / enzymology*, pathology* Humans Immunohistochemistry Macrophages / enzymology*, pathology* Male Matrix Metalloproteinase 2 Matrix Metalloproteinase 9 Metalloendopeptidases / analysis Middle Aged Necrosis Temporal Arteries / enzymology, pathology |
| Chemical | |
Reg. No./Substance:
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EC 3.4.24.-/Collagenases; EC 3.4.24.-/Gelatinases; EC 3.4.24.-/Metalloendopeptidases; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.35/Matrix Metalloproteinase 9 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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