| Macrophages and tissue injury: agents of defense or destruction? | |
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MedLine Citation:
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PMID: 20887196 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The past several years have seen the accumulation of evidence demonstrating that tissue injury induced by diverse toxicants is due not only to their direct effects on target tissues but also indirectly to the actions of resident and infiltrating macrophages. These cells release an array of mediators with cytotoxic, pro- and anti-inflammatory, angiogenic, fibrogenic, and mitogenic activity, which function to fight infections, limit tissue injury, and promote wound healing. However, following exposure to toxicants, macrophages can become hyperresponsive, resulting in uncontrolled or dysregulated release of mediators that exacerbate acute tissue injury and/or promote the development of chronic diseases such as fibrosis and cancer. Evidence suggests that the diverse activity of macrophages is mediated by distinct subpopulations that develop in response to signals within their microenvironment. Understanding the precise roles of these different macrophage populations in the pathogenic response to toxicants is key to designing effective treatments for minimizing tissue damage and chronic disease and for facilitating wound repair. |
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Authors:
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Debra L Laskin; Vasanthi R Sunil; Carol R Gardner; Jeffrey D Laskin |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Annual review of pharmacology and toxicology Volume: 51 ISSN: 1545-4304 ISO Abbreviation: Annu. Rev. Pharmacol. Toxicol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7607088 Medline TA: Annu Rev Pharmacol Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 267-88 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Rutgers University, Piscataway, New Jersey 08854, USA. laskin@eohsi.rutgers.edu |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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AR055073/AR/NIAMS NIH HHS; CA132624/CA/NCI NIH HHS; ES004738/ES/NIEHS NIH HHS; ES005022/ES/NIEHS NIH HHS; GM034310/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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