| Macrophages, oxysterols and atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 20838002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Macrophages play central roles in immunity and homeostasis, and contribute to the pathogenesis of atherosclerosis through their accumulation of cholesterol and the production of inflammatory mediators and cytokines. Recent studies indicate that oxysterols influence diverse aspects of macrophage biology. Rather than simply being intermediates of cholesterol catabolism, oxysterols are also potent bioactive lipids that regulate lipid metabolism, immune function, and cytotoxicity. These functions are mediated by specific oxysterol sensors, including liver X receptors (LXR), Insigs, and members of the oxysterol binding protein (OSBP) and OSBP-related protein family. The mechanisms of oxysterol-induced functions and their physiological roles in macrophages are reviewed. |
| | |
Authors:
|
Norihito Shibata; Christopher K Glass |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-09-11 |
Journal Detail:
|
Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-30 Completed Date: 2011-02-23 Revised Date: 2012-02-16 |
Medline Journal Info:
|
Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
|
Languages: eng Pagination: 2045-51 Citation Subset: IM |
Affiliation:
|
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Atherosclerosis
/
etiology* Humans Macrophages / immunology*, physiology Receptors, Steroid Sterols* |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Steroid; 0/Sterols; 0/oxysterol binding protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Probabilistic mixture regression models for alignment of LC-MS data.
Next Document: Dose-dependent reduction in pulmonary vascular resistance with epoprostenol in pulmonary arterial hy...