Document Detail

Macrophage-rich reaction in lymph nodes as a mimic of metastatic renal cell carcinoma on fine needle aspiration. A case report.
MedLine Citation:
PMID:  11393085     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Renal cell carcinomas have a high metastatic potential. Many of them are occult at initial presentation and mimic a primary neoplasm of the metastatic site. However, not all lymph node enlargements in a patient with a history of renal cell carcinoma are due to metastasis. Foamy macrophages can mimic metastatic renal cell carcinoma cells. CASE: A 60-year-old male with a known diagnosis of renal cell carcinoma of clear cell type developed enlarged neck nodes 44 months after the diagnosis. These were aspirated to yield cystic fluid that, on smears, showed numerous clear cells with low nuclear grade. Immunohistochemical stains revealed these cells to be foamy macrophages (CD68 immunoreactive) and not metastatic renal cell carcinoma, as had been suspected on initial examination of Diff-Quik and Papanicolaou-stained smears. CONCLUSION: Immunohistochemistry is a valuable adjunct in avoiding a false diagnosis of metastatic carcinoma in macrophage-rich nodal reactions in patients with a history of renal cell carcinoma.
M Singh; E Wu; K R Shroyer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cytologica     Volume:  45     ISSN:  0001-5547     ISO Abbreviation:  Acta Cytol.     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-06-06     Completed Date:  2001-07-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370307     Medline TA:  Acta Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  454-8     Citation Subset:  IM    
Department of Pathology, B216, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, Colorado 80262, USA.
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MeSH Terms
Antigens, CD / analysis,  immunology
Antigens, Differentiation, Myelomonocytic / analysis,  immunology
Biopsy, Needle*
Carcinoma, Renal Cell / pathology*,  secondary
Diagnosis, Differential
Foam Cells* / chemistry,  pathology
Kidney Neoplasms / pathology*
Lymph Nodes* / pathology
Lymphadenitis / pathology*
Lymphatic Metastasis
Middle Aged
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/CD68 antigen, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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