| Macrophage responses to bacterial toxins: a balance between activation and suppression. | |
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MedLine Citation:
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PMID: 21717083 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Toxins secreted by bacteria can impact the host in a number of different ways. In some infections, toxins play a crucial and central role in pathogenesis (i.e., anthrax), while in other bacterial infections, the role of toxins is less understood. The cholesterol-dependent cytolysins (CDCs), of which streptolysin O is a prototype, are a class of pore-forming toxins produced by many gram-positive bacteria and have only been studied in a few experimental infection models. Our laboratory has demonstrated that CDCs have effects on macrophages that are both pro- and anti-inflammatory. Here, we review evidence that CDCs promote inflammation by driving secretion of IL-1β and HMGB-1 from macrophages in a NLRP3-dependent manner, while also causing shedding of membrane microvesicles from cells that can interact with macrophages and inhibit TNF-α release. CDCs thus impact macrophage function in ways that may be both beneficial and detrimental to the host. |
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Authors:
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Peter A Keyel; Michelle E Heid; Russell D Salter |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-30 |
Journal Detail:
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Title: Immunologic research Volume: - ISSN: 1559-0755 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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