Document Detail

Macrophage response to microbial pathogens: modulation of the expression of adhesion, CD14, and MHC class II molecules by viruses, bacteria, protozoa and fungi.
MedLine Citation:
PMID:  7544909     Owner:  NLM     Status:  MEDLINE    
The ability of inactivated viruses, bacteria, protozoa and fungi to modulate the expression of CD14, CD49d, CD49f, CD11a (LFA-1), and CD54 (ICAM-1) molecules in unprimed bone marrow-derived mononuclear phagocytes (BMM phi) was investigated by means of flow cytometry. Incubation with bacterial agents resulted in the large majority of experimental situations in enhanced expression of these macrophage surface molecules. In contrast, viruses and fungi down-regulated the expression of several adhesion receptors, especially integrins. Amplification of MHC class II expression triggered in macrophages by interferon gamma was clearly inhibited by viruses, bacteria, protozoa and fungi. The findings explain earlier results showing that, under the same experimental conditions, bacterial agents are, for the most part, potent stimulators of secretory and cell-mediated macrophage activities while viruses, protozoa and fungi are poor in this respect.
R Keller; R Keist; P Joller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  42     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-10-04     Completed Date:  1995-10-04     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  337-44     Citation Subset:  IM    
Department of Pathology, University of Zurich, Switzerland.
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MeSH Terms
Antigens, CD / metabolism*
Antigens, CD14
Antigens, Differentiation, Myelomonocytic / metabolism*
Antigens, Surface / metabolism
Bacteria / immunology*
Bone Marrow Cells
Cell Adhesion Molecules / metabolism*
Eukaryota / immunology*
Flow Cytometry
Fungi / immunology*
Histocompatibility Antigens Class II / metabolism*
Integrins / metabolism*
Interferon-gamma / pharmacology
Macrophage Activation
Macrophages / metabolism*
Rats, Inbred Strains
Viruses / immunology*
Reg. No./Substance:
0/Antigens, CD; 0/Antigens, CD14; 0/Antigens, Differentiation, Myelomonocytic; 0/Antigens, Surface; 0/Cell Adhesion Molecules; 0/Histocompatibility Antigens Class II; 0/Integrins; 82115-62-6/Interferon-gamma

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