| Macrophage proteases can modify low density lipoproteins to increase their uptake by macrophages. | |
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MedLine Citation:
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PMID: 2201569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When low density lipoprotein (LDL) was incubated with sonicated macrophages at acidic pH, its protein moiety was partially degraded by cathepsins B and D. The reisolated LDL was taken up by intact macrophages up to about 20 times as fast as control LDL. LDL proteolysis and its enhanced uptake could be inhibited almost entirely by the selective protease inhibitors leupeptin and pepstatin. If macrophages in atherosclerotic lesions were to release acidic proteases (either by exocytosis or following cell death) and these were to modify LDL, this may help to explain why so much cholesteryl ester accumulates in these cells. |
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Authors:
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D S Leake; S M Rankin; J Collard |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 269 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1990 Aug |
Date Detail:
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Created Date: 1990-09-27 Completed Date: 1990-09-27 Revised Date: 2009-09-29 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 209-12 Citation Subset: IM |
Affiliation:
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Division of Biomedical Sciences, King's College London (University of London), UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apolipoprotein B-100 Apolipoproteins B / metabolism Lipoproteins, LDL / metabolism* Macrophages / enzymology, metabolism* Mice Peptide Hydrolases / metabolism* Protease Inhibitors / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein B-100; 0/Apolipoproteins B; 0/Lipoproteins, LDL; 0/Protease Inhibitors; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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