Document Detail

Macrophage populations of different origins have distinct susceptibilities to lipid peroxidation induced by beta-haematin (malaria pigment).
MedLine Citation:
PMID:  9744797     Owner:  NLM     Status:  MEDLINE    
We investigated the susceptibility of peritoneal mouse macrophages and macrophage and microglia cell lines to the peroxidative activity of beta-haematin, the synthetic polymer identical to native malaria pigment. The extent of lipid peroxidation, measured as production of thiobarbituric acid reactive substances (TBARS), was greater for peritoneal macrophages than for cell lines and microglia cells. TBARS production apparently was not attributable to the release of free iron from the protoporphyrin moiety, but related to lower glutathione content and different lipid composition of the cell membrane. These findings offer a new interpretation for the contentious immunomodulatory effects of beta-haematin reported for phagocytes of different origins.
F Omodeo-Salè; N Basilico; M Folini; P Olliaro; D Taramelli
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  FEBS letters     Volume:  433     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-10-08     Completed Date:  1998-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  215-8     Citation Subset:  IM    
Istituto di Fisiologia Generale e Chimica Biologica, Università di Milano, Milan, Italy.
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MeSH Terms
Cell Line
Cells, Cultured
Cholesterol / metabolism
Fatty Acids / metabolism
Glutathione / metabolism
Glutathione Reductase / metabolism
Hemin / pharmacology*
Lipid Peroxidation / drug effects,  physiology*
Macrophages / cytology,  drug effects,  physiology*
Macrophages, Peritoneal / cytology,  drug effects,  physiology
Mice, Inbred C3H
Microglia / cytology,  drug effects,  physiology*
Phospholipids / metabolism
Thiobarbituric Acid Reactive Substances / analysis
Reg. No./Substance:
0/Fatty Acids; 0/Phospholipids; 0/Thiobarbituric Acid Reactive Substances; 16009-13-5/Hemin; 57-88-5/Cholesterol; 70-18-8/Glutathione; EC Reductase

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