| Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. | |
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MedLine Citation:
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PMID: 12401408 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mononuclear phagocytes are versatile cells that can express different functional programs in response to microenvironmental signals. Fully polarized M1 and M2 (or alternatively activated) macrophages are the extremes of a continuum of functional states. Macrophages that infiltrate tumor tissues are driven by tumor-derived and T cell-derived cytokines to acquire a polarized M2 phenotype. These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression. |
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Authors:
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Alberto Mantovani; Silvano Sozzani; Massimo Locati; Paola Allavena; Antonio Sica |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Trends in immunology Volume: 23 ISSN: 1471-4906 ISO Abbreviation: Trends Immunol. Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-10-28 Completed Date: 2002-12-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 100966032 Medline TA: Trends Immunol Country: England |
Other Details:
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Languages: eng Pagination: 549-55 Citation Subset: IM |
Affiliation:
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Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I-20157 Milan, Italy. mantovani@marionegri.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Chemokines / biosynthesis Cytokines / biosynthesis Humans Macrophage Activation Macrophages / classification, immunology*, pathology Models, Immunological Neoplasms / immunology*, pathology Phagocytes / classification, immunology, pathology Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/Cytokines |
| Comments/Corrections | |
Comment In:
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Trends Immunol. 2003 May;24(5):232-3; author reply 234
[PMID:
12738414
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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