| Macrophage polarization and bacterial infections. | |
| | |
MedLine Citation:
|
PMID: 21311324 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
PURPOSE OF REVIEW: Macrophages are the first line of defense against pathogens, and the mode of their activation will determine the success or failure of the host response to pathogen aggression. Based on limited numbers of markers, activated macrophages can be classified as classically activated (M1) macrophages that support microbicidal activity or alternatively activated (M2) macrophages that are not competent to eliminate pathogens. The development of high-throughput gene expression methods affords a reappraisal of the concept of macrophage activation in human infectious diseases. RECENT FINDINGS: By combining microarray data and conventional approaches, it is becoming clear that the M1 polarization program is associated with gastrointestinal infections (e.g. typhoid fever and Helicobacter pylori gastritis) and active tuberculosis. An M2 signature is observed in lepromatous leprosy, Whipple's disease, and localized infections (keratitis, chronic rhinosinusitis). However, these findings could not be predicted from the analysis of the M1/M2 programs of macrophages stimulated in vitro. SUMMARY: The reappraisal of macrophage polarization by high-throughput methods is critical to understanding the role of macrophage polarization in infectious diseases. Only the identification of individual profiles will support promising therapeutic approaches based on target determination. |
| | |
Authors:
|
Jean-Louis Mège; Vikram Mehraj; Christian Capo |
Related Documents
:
|
14500514 - An attenuated strain of the facultative intracellular bacterium francisella tularensis ... 15791954 - The role of host cell death in salmonella infections. 16786854 - Deoxynivalenol and satratoxin g potentiate proinflammatory cytokine and macrophage inhi... 9716104 - Priming of t-cell responses in mice by porins of salmonella typhimurium. 18401834 - Maternal perinatal undernutrition impairs chromaffin cells proliferation in the postnat... 15157164 - An apoptosis differentiation programme in human polymorphonuclear leucocytes. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Current opinion in infectious diseases Volume: 24 ISSN: 1473-6527 ISO Abbreviation: Curr. Opin. Infect. Dis. Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-04-22 Completed Date: 2011-08-02 Revised Date: 2012-01-31 |
Medline Journal Info:
|
Nlm Unique ID: 8809878 Medline TA: Curr Opin Infect Dis Country: United States |
Other Details:
|
Languages: eng Pagination: 230-4 Citation Subset: IM |
Affiliation:
|
Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 6236, Institut Fédératif de Recherche 48, Université de la Méditerranée, Marseille, France. jean-louis.mege@univmed.fr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bacterial Infections
/
immunology* Gene Expression Profiling Humans Macrophage Activation* Macrophages / immunology* Microarray Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of the endocannabinoid system in islet biology.
Next Document: Gene-gene and gene-environment interactions defining lipid-related traits.