Document Detail

Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products.
MedLine Citation:
PMID:  15110749     Owner:  NLM     Status:  MEDLINE    
Clearance of apoptotic cells by phagocytosis plays an important role in the resolution of an inflammatory response. Macrophages interacting with extracellular matrix (ECM) proteins upregulate their phagocytic capacity. Cigarette smoke contains highly reactive carbonyls that modify proteins which directly/indirectly affects cellular function. We observed, in vitro, that human macrophages interacting with carbonyl or cigarette smoke modified ECM proteins dramatically down regulated their ability to phagocytose apoptotic neutrophils. We also show that this interaction with carbonyl-adduct modified ECM proteins led to increased macrophage adhesion in vitro. We hypothesise that changes in the ECM environment as a result of cigarette smoking affect the ability of macrophages to remove apoptotic cells. Moreover, we postulate that this decreased phagocytic activity was as a result of sequestration of receptors involved in the uptake of apoptotic cells towards that of recognition of carbonyl adducts on the modified ECM proteins leading to increased macrophage adhesion.
Paul A Kirkham; Gillian Spooner; Irfan Rahman; Adriano G Rossi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  318     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-27     Completed Date:  2004-06-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32-7     Citation Subset:  IM    
Novartis Institute for Biomedical Research (Horsham), West Sussex, UK.
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MeSH Terms
Aldehydes / pharmacology
Antigens, CD44 / physiology
Apoptosis / physiology
Cell Adhesion / drug effects
Collagen Type IV / physiology
Extracellular Matrix / physiology*
Extracellular Matrix Proteins / physiology*
Fibronectins / physiology
Lipid Peroxidation / drug effects
Macrophages / metabolism,  physiology*
Neutrophils / cytology*,  metabolism
Smoking / adverse effects*,  pathology
U937 Cells
Reg. No./Substance:
0/Aldehydes; 0/Antigens, CD44; 0/Collagen Type IV; 0/Extracellular Matrix Proteins; 0/Fibronectins; 29343-52-0/4-hydroxy-2-nonenal

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