Document Detail

Macrophage migration inhibitory factor-A potential diagnostic tool in severe burn injuries?
MedLine Citation:
PMID:  19540674     Owner:  NLM     Status:  MEDLINE    
Serum macrophage migration inhibitory factor (MIF) and procalcitonin (PCT) concentrations as well as leucocyte numbers were evaluated in a retrospective study with 23 patients with severe burn injuries. The MIF and PCT concentrations as well as the number of leucocytes (LEU) were monitored over a period of 5 days. The total body surface area (TBSA) and sepsis-related organ failure assessment (SOFA) scores were also evaluated. The MIF, PCT concentrations and leucocyte counts were profoundly increased in all patients with severe burn wounds. At the time of admission into the intensive care unit, no significant differences were observed for the MIF and PCT levels between patients with a TBSA<60% (Group 1) and patients with a TBSA>60% (Group 2). After 48 h, however, the MIF and PCT levels reached very high levels in a subgroup of the patients, whereas these levels became normal again in other subgroups. The group of patients with a TBSA>60% was, therefore, subdivided in three groups (subgroups 2a-c). The MIF and PCT data pairs in these subgroups appeared to correlate in an inhomogeneous manner. These levels in the subgroup 2a (i.e., lethal within 5 days) were strongly elevated over those observed in Group 1 (TBSA<60%) and highly increased concentrations of both MIF and PCT correlated with lethal outcome. The combined determination of MIF and PCT might, therefore, be useful to discriminate between post-burn inflammation and systemic inflammatory response syndrome (SIRS) or sepsis with lethal outcome.
Gerrit Grieb; David Simons; Andrzej Piatkowski; Jürgen Bernhagen; Guy Steffens; Norbert Pallua
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-21
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  36     ISSN:  1879-1409     ISO Abbreviation:  Burns     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-03-15     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  335-42     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ltd and ISBI. All rights reserved.
Department of Plastic Surgery, Hand and Burn Surgery, Medical Faculty, RWTH Aachen University, Germany.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Burns / blood*,  complications*,  pathology
Calcitonin / blood
Diagnosis, Differential
Inflammation / diagnosis,  etiology
Leukocyte Count
Macrophage Migration-Inhibitory Factors / blood*
Middle Aged
Protein Precursors / blood
Retrospective Studies
Sepsis / diagnosis,  etiology
Systemic Inflammatory Response Syndrome / diagnosis,  etiology
Trauma Severity Indices
Reg. No./Substance:
0/Biological Markers; 0/Macrophage Migration-Inhibitory Factors; 0/Protein Precursors; 56645-65-9/procalcitonin; 9007-12-9/Calcitonin

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