| MACROPHAGE MIGRATION INHIBITORY FACTOR IN THE NUCLEUS OF SOLITARY TRACT DECREASES BLOOD PRESSURE IN SHR. | |
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MedLine Citation:
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PMID: 22997157 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS: Macrophage migration inhibitory factor (MIF) is an intracellular inhibitor of the central nervous system actions of angiotensin II on blood pressure. Considering that angiotensin II actions at the nucleus of the solitary tract are important for the maintenance of hypertension in spontaneously hypertensive rats (SHR), we tested if increased MIF expression in the nucleus of the solitary tract of SHR alters the baseline high blood pressure in these rats.Methods and ResultsEight-week old SHR or normotensive rats were microinjected with the vector AAV2-CBA-MIF into the nucleus of the solitary tract, resulting in MIF expression predominantly in neurons. Rats also underwent recordings of mean arterial blood pressure and heart rate (via telemetry devices implanted in the abdominal aorta), cardiac- and baroreflex function. Injections of AAV2-CBA-MIF into the nucleus of the solitary tract of SHR produced significant decreases in mean arterial blood pressure, ranging from 10 to 20 mmHg, compared with age-matched SHR that had received identical microinjections of the control vector AAV2-CBA-eGFP. This lowered mean arterial blood pressure in SHR was maintained through the end of the experiment at 31 days, and was associated with an improvement in baroreflex function to values observed in normotensive rats. In contrast to SHR, similar increased MIF expression in the nucleus of the solitary tract of normotensive rats produced no changes in baseline MAP and baroreflex function. CONCLUSIONS: These results indicate that increased expression of MIF within nucleus of the solitary tract neurons of SHR lowers blood pressure and restores baroreflex function. |
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Authors:
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André Henrique Freiria-Oliveira; Graziela Torres Blanch; Hongwei Li; Eduardo Colombari; Débora Simões Almeida Colombari; Colin Sumners |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-20 |
Journal Detail:
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Title: Cardiovascular research Volume: - ISSN: 1755-3245 ISO Abbreviation: Cardiovasc. Res. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Physiology and Functional Genomics and McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, FL, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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