| Macrophage migration inhibitory factor in the human prostate: identification and immunocytochemical localization. | |
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MedLine Citation:
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PMID: 10334104 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Macrophage migration inhibitory factor (MIF) is a lymphokine originally identified for its capacity to inhibit the random migration of macrophages. Recent data have further extended knowledge of the physiological role of this protein, showing that MIF is produced by several human organs and tissues. The present study was intended to evaluate the expression and tissutal localization of MIF in the human prostate. METHODS: Prostate tissues were obtained from patients undergoing surgical adenomectomy for benign prostatic hyperplasia and were analyzed by Western blot, reverse transcriptase-polymerase chain reaction, immunohistochemistry, and immunoelectron microscopy. RESULTS. The presence of both MIF protein and mRNA was demonstrated in the prostate. Immunocytochemical studies localized MIF protein in the secretory luminal epithelial and basal layer cells. CONCLUSIONS: The present study demonstrated that the human prostate is a site of MIF synthesis. Macrophages populate the human prostate and represent an important mechanism of defense of integrity and functionality of the gland. It is speculated that MIF might play a role in preserving prostate physiological activity by maintaining its macrophage population. |
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Authors:
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F Arcuri; M T del Vecchio; M M de Santi; A V Lalinga; V Pallini; L Bini; S Bartolommei; S Parigi; M Cintorino |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Prostate Volume: 39 ISSN: 0270-4137 ISO Abbreviation: Prostate Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-05-26 Completed Date: 1999-05-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8101368 Medline TA: Prostate Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 159-65 Citation Subset: IM |
Affiliation:
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Institute of Pathological Anatomy and Histology, University of Siena, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blotting, Western Humans Immunohistochemistry Macrophage Activation Macrophage Migration-Inhibitory Factors / analysis*, physiology Male Prostatic Hyperplasia / metabolism*, pathology RNA, Messenger / analysis, physiology Reverse Transcriptase Polymerase Chain Reaction |
| Chemical | |
Reg. No./Substance:
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0/Macrophage Migration-Inhibitory Factors; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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