Document Detail

Macrophage migration inhibitory factor (MIF)--its role in catecholamine metabolism.
MedLine Citation:
PMID:  10644007     Owner:  NLM     Status:  MEDLINE    
Macrophage migration inhibitory factor (MIF) was originally identified several decades ago as a lymphokine-derived protein that inhibited monocyte migration. Recently, it has been reported that MIF has D-dopachrome tautomerase, phenylpyruvate tautomerase and thiol protein oxidoreductase activities, although the physiological significance of those activities is not yet clear. Here we show that MIF is able to catalyze the conversion of dopaminechrome and norepinephrinechrome, toxic quinone products of the neurotransmitters dopamine and norepinephrine, respectively, to indole derivatives that may serve as precursors to neuromelanin. Since MIF is highly expressed in human brain, these observations raise the possibility that MIF participates in a detoxification pathway for catecholamine products and could therefore have an important role for neural tissues. The potential role of MIF in the formation of neuromelanin from catecholamines is also an extremely interesting possibility.
J Matsunaga; D Sinha; F Solano; C Santis; G Wistow; V Hearing
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cellular and molecular biology (Noisy-le-Grand, France)     Volume:  45     ISSN:  0145-5680     ISO Abbreviation:  Cell. Mol. Biol. (Noisy-le-grand)     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-03-15     Completed Date:  2000-03-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9216789     Medline TA:  Cell Mol Biol (Noisy-le-grand)     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  1035-40     Citation Subset:  IM    
N.I.H., Laboratory of Cell Biology, Bethesda, MD 20892, USA.
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MeSH Terms
Brain / metabolism
Catecholamines / metabolism*
Dopamine / metabolism
Indoles / metabolism
Intramolecular Oxidoreductases / metabolism
Macrophage Migration-Inhibitory Factors / physiology*
Melanins / biosynthesis
Nerve Tissue Proteins / metabolism
Norepinephrine / metabolism
Recombinant Fusion Proteins / metabolism
Reg. No./Substance:
0/Catecholamines; 0/Indoles; 0/Macrophage Migration-Inhibitory Factors; 0/Melanins; 0/Nerve Tissue Proteins; 0/Recombinant Fusion Proteins; 0/epinephrinechrome; 0/neuromelanin; 0/norepinephrinechrome; 3131-52-0/5,6-dihydroxyindole; 4790-08-3/5,6-dihydroxy-2-indolylcarboxylic acid; 51-41-2/Norepinephrine; 67992-45-4/dopaminechrome; EC 5.3.-/Intramolecular Oxidoreductases; EC isomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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