| Macrophage migration inhibitory factor -173 polymorphism and risk of coronary alterations in children with Kawasaki disease. | |
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MedLine Citation:
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PMID: 20149326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the possible relationship between MIF -173 polymorphism and susceptibility to, and severity of, Kawasaki disease (KD) in a cohort of Italian patients. METHODS: Sixty-nine patients (43 F, 26 M, median age 29 months, range 3-135 months) with KD and 60 sex-matched healthy caucasian children were genotyped for MIF-173. Typing of the MIF gene -173 G/C was performed by PCR and restriction fragment length polymorphism. RESULTS: Eight out of 69 (12%) KD children were non-responders: 7 required an additional IVIG infusion, while 1 received 2 IVIG infusions and then steroid administration. 9/69 (13%) KD children developed coronary artery abnormalities (CAA) during the second to fourth week of disease, and 4 of them required an additional IVIG infusion. MIF genotyping did not show significant differences between patients and controls. KD patients carrying a MIF -173*C allele developed CAA more frequently than those without MIF- (7/9 77.8% vs. 16/60 26.7%, OR 9.6, 95% CI 1.80-21.2, p<0.005). Non-responders to a single IVIG infusion carried the MIF -173*C allele more frequently than responders (6/8 = 75% vs. 17/61 = 28%, OR 5.1, 95% CI 1.42-22.31 p<0.014). In multiple regression analysis, KD patients carrying a MIF -173*C allele were found to have an increased risk of coronary involvement (OR 7.7, 95% CI 1.36-16.1, p=0.021). CONCLUSIONS: We showed that children carrying the MIF polymorphism -173*C had a higher percentage of CAA. A potential relationship between a MIF polymorphism and risk of CAA in KD might be considered. |
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Authors:
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G Simonini; E Corinaldesi; C Massai; F Falcini; F Fanti; M De Martino; R Cimaz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental rheumatology Volume: 27 ISSN: 0392-856X ISO Abbreviation: Clin. Exp. Rheumatol. Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2010-02-12 Completed Date: 2010-03-31 Revised Date: 2011-01-12 |
Medline Journal Info:
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Nlm Unique ID: 8308521 Medline TA: Clin Exp Rheumatol Country: Italy |
Other Details:
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Languages: eng Pagination: 1026-30 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Rheumatology Unit, A. Meyer Children's Hospital, Florence, Italy. gabriele.simonini@unifi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Child Child, Preschool Coronary Vessel Anomalies / genetics* Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Immunoglobulins, Intravenous / therapeutic use Infant Italy Macrophage Migration-Inhibitory Factors / genetics* Male Mucocutaneous Lymph Node Syndrome / genetics*, therapy Mutation / genetics Polymerase Chain Reaction Polymorphism, Single Nucleotide / genetics* Risk Factors Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Intravenous; 0/Macrophage Migration-Inhibitory Factors |
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