Document Detail

Macrophage inhibitory cytokine-1: a new player in melanoma development.
MedLine Citation:
PMID:  19148214     Owner:  NLM     Status:  MEDLINE    
Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the TGF-beta superfamily. Although it has been reported to exhibit both tumorigenic and antitumorigenic activities, Boyle et al. report in this issue that MIC-1 expression was correlated with the tumorigenicity of melanoma cells. The elucidation of signaling pathways around MIC-1 might contribute to prospective targeting therapy for melanoma.
Toshiharu Yamashita; Akihiro Yoneta; Tokimasa Hida
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  129     ISSN:  1523-1747     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-16     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  262-4     Citation Subset:  IM    
Department of Dermatology, Sapporo Medical University, Sapporo, Japan.
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MeSH Terms
Gene Expression Regulation, Neoplastic
Growth Differentiation Factor 15 / genetics*
Melanoma / genetics*,  immunology*
Skin Neoplasms / genetics*,  immunology*
Reg. No./Substance:
0/GDF15 protein, human; 0/Growth Differentiation Factor 15
Comment On:
J Invest Dermatol. 2009 Feb;129(2):383-91   [PMID:  18754039 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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