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Macrophage infiltration and stress-signaling in omental and subcutaneous adipose tissue in diabetic pregnancies.
MedLine Citation:
PMID:  24111719     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
METHODS: Paired omental (OM) and abdominal subcutaneous (SC) fat samples were collected from 11 GDM and 20 normal pregnancies during cesarean delivery. Tissues were stained to detect macrophages, and analyzed to assess MAP-kinases.
RESULTS: OM had higher macrophage counts than SC in GDM (6.10±2.20 vs. 2.53±1.45, P=0.04), but not in normal pregnancies (p=0.346). GDM pregnancies had more macrophages than normal pregnancies in OM (6.10±2.20 vs. 1.29±0.55, P=0.01), while only a trend was observed in SC fat (p=0.08). Significant correlation (R=0.619, p=0.005) was observed between OM-macrophage infiltration and insulin resistance. Using multivariate analysis, only obesity independently associated with GDM. Expression of total p38MAP-kinase was higher in OM vs. SC in both normal and GDM pregnancies, without significant differences between these groups. However, expression of activated p-p38MAP-kinase, and its upstream kinase MKK4, was comparable between fat depots.
CONCLUSION: GDM pregnancies demonstrate increased macrophage infiltration to OM fat, correlating with higher insulin resistance. As in non-pregnant-patients obesity and OM macrophage infiltration may be on the same causal pathway, leading to GDM, without activation of p38MAP-kinase signaling.
Authors:
Harlev Avi; Aricha-Tamir Barak; Shaco-Levy Ruthy; Tarnovscki Tania; Bashan Nava; Rudich Assaf; Sheiner Eyal; Press Fernanda; Wiznitzer Arnon
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-10
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Israel.
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