| Macrophage colony-stimulating factor in the pathogenesis of HIV infection: potential target for therapeutic intervention. | |
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MedLine Citation:
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PMID: 18040789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Macrophage colony stimulating factor (M-CSF) appears to play a major role in promoting and maintaining reservoirs of human immunodeficiency virus type 1 (HIV-1) in infected individuals. HIV-1 infection induces production of M-CSF by macrophages, which in turn promotes further infection of macrophages via increases in CD4 and CCR5 receptors, as well as increases in virus gene expression. M-CSF promotes the ontogeny and survival of macrophages, contributing to both the number and longevity of these infected cells. M-CSF dysregulation promotes the differentiation of monocytes toward macrophages and osteoclasts and at the same time may inhibit differentiation toward dendritic cells, resulting in immune impairment. The potential role of M-CSF in HIV-associated end organ diseases including HIV-associated dementia, HIV-associated nephropathy, and osteoporosis is discussed. This review emphasizes the need for developing M-CSF antagonists for treatment of HIV-1-infected patients. |
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Authors:
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Valerie Haine; Tracy Fischer-Smith; Jay Rappaport |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Volume: 1 ISSN: 1557-1904 ISO Abbreviation: J Neuroimmune Pharmacol Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2007-11-27 Completed Date: 2007-12-27 Revised Date: 2008-03-17 |
Medline Journal Info:
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Nlm Unique ID: 101256586 Medline TA: J Neuroimmune Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 32-40 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, Center for Neurovirology, Temple University School of Medicine, 1900 N. 12th Street, Philadelphia, PA 19122, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / immunology HIV Infections / immunology*, metabolism HIV-1 / immunology* Humans Macrophage Colony-Stimulating Factor / immunology*, metabolism*, therapeutic use Macrophages / cytology, metabolism*, virology |
| Chemical | |
Reg. No./Substance:
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81627-83-0/Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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