Document Detail

Macrophage colony-stimulating factor (M-CSF) induces migration in osteoclasts in vitro.
MedLine Citation:
PMID:  8216275     Owner:  NLM     Status:  MEDLINE    
It has recently been shown that M-CSF is essential for osteoclast formation and survival. Paradoxically, the cytokine inhibits bone resorption by isolated osteoclasts. This implies that it may stimulate some function in osteoclasts not directly related to the bone resorptive process itself. We now report that M-CSF stimulates migration in isolated rat osteoclasts. This was achieved predominantly by a 3-8-fold increase in the proportion of osteoclasts demonstrating migration, combined with an increase in the area of substrate covered (43-96%) by each migrating cell. This action of M-CSF on migration is the inverse of its effect on resorption, wherein it has been previously found to reduce the proportion of osteoclasts that resorb bone and suggests that migration and resorption might represent alternative states of osteoclast behaviour. The results also suggest that osteoblast-derived M-CSF might play a role in the induction and regulation of localisation of these cells in bone.
J Owens; T J Chambers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  195     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-10-25     Completed Date:  1993-10-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1401-7     Citation Subset:  IM    
Dept. of Histopathology, St George's Hospital Medical School, London, UK.
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MeSH Terms
Animals, Newborn
Bone and Bones / cytology
Cell Movement / drug effects*
Cells, Cultured
Macrophage Colony-Stimulating Factor / pharmacology*
Osteoclasts / drug effects,  physiology*
Reg. No./Substance:
81627-83-0/Macrophage Colony-Stimulating Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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