Document Detail

Macrophage activity in mouse pregnancy.
MedLine Citation:
PMID:  551169     Owner:  NLM     Status:  MEDLINE    
Antigen handling and clearance by macrophages during mouse pregnancy has been examined by monitoring blood levels of 125I-labelled polyvinyl pryrrolidone (PVP) at different times following its intravenous injection into mated females. PVP clearance is significantly reduced between days 12 and 14 of pregnancy in both syngeneic and allogeneic matings. No significant differences were observed between virgin and mated females at earlier or later states of pregnancy. The findings are discussed in relation to the possible role of macrophages in the immunoregulatory processes involved in the maintenance of the foetus as an intrauterine allograft.
S Nicklin; W D Billington
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of reproductive immunology     Volume:  1     ISSN:  0165-0378     ISO Abbreviation:  J. Reprod. Immunol.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1980-11-24     Completed Date:  1980-11-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8001906     Medline TA:  J Reprod Immunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  117-26     Citation Subset:  IM    
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MeSH Terms
Blood Volume
Liver / metabolism
Macrophages / immunology*
Mice, Inbred A
Mice, Inbred C57BL
Placenta / metabolism
Povidone / metabolism
Spleen / metabolism
Time Factors
Reg. No./Substance:

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