| Macrophage activation syndrome: serological markers and treatment with anti-thymocyte globulin. | |
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MedLine Citation:
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PMID: 19297252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two patients presented at the University of Rochester Medical Center with a febrile illness, cytopenias, organ failure (liver failure or respiratory failure), and markedly elevated serum ferritin and sIL-2R. A diagnosis of probable macrophage activation syndrome was made. Both patients failed initial therapy with steroids and cyclosporine, either due to toxicity or lack of efficacy. Both patients responded dramatically to rabbit anti-thymocyte globulin (ATG). |
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Authors:
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Andreea Coca; Kemp W Bundy; Bethany Marston; Jennifer Huggins; R John Looney |
Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2009-03-17 |
Journal Detail:
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Title: Clinical immunology (Orlando, Fla.) Volume: 132 ISSN: 1521-7035 ISO Abbreviation: Clin. Immunol. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-08 Completed Date: 2009-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 10-8 Citation Subset: IM |
Affiliation:
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University of Rochester, Department of Medicine, Allergy Immunology Rheumatology Division, Room G-6427C, 601 Elmwood Avenue, Rochester, New York 14642, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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blood Antigens, Differentiation, Myelomonocytic / blood Antilymphocyte Serum / therapeutic use* Biological Markers / blood* Female Ferritins / blood Humans Immunosuppressive Agents / therapeutic use Macrophage Activation Syndrome / blood*, diagnosis, drug therapy* Receptors, Cell Surface / blood Receptors, Interleukin-2 / blood Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, Differentiation, Myelomonocytic; 0/Antilymphocyte Serum; 0/Biological Markers; 0/CD163 antigen; 0/Immunosuppressive Agents; 0/Receptors, Cell Surface; 0/Receptors, Interleukin-2; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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