| Macrophage signaling pathways: a novel target in renal disease. | |
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MedLine Citation:
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PMID: 20620676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monocytes/macrophages are a heterogeneous cell population that play a critical role in host defense and tissue homeostasis. However, macrophage activation during acute and chronic inflammation can result in macrophage-mediated renal injury in a variety of settings, including proliferative glomerulonephritis. Macrophages can be activated via a number of intracellular signaling pathways (eg, c-Jun amino terminal kinase, p38 mitogen-activated protein kinase, FcR/Syk, Janus kinase/signal transducer and activator of transcription) that induce production of mediators of renal injury. Thus, targeting selected macrophage signaling pathways is a potential therapeutic strategy to suppress macrophage-mediated renal injury while leaving intact the desirable macrophage functions of host defense and tissue repair. |
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Authors:
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Frank Y Ma; Yohei Ikezumi; David J Nikolic-Paterson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Seminars in nephrology Volume: 30 ISSN: 1558-4488 ISO Abbreviation: Semin. Nephrol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-12-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8110298 Medline TA: Semin Nephrol Country: United States |
Other Details:
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Languages: eng Pagination: 334-44 Citation Subset: IM |
Affiliation:
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Department of Nephrology and Monash University Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cytokines / antagonists & inhibitors Humans JNK Mitogen-Activated Protein Kinases / antagonists & inhibitors Kidney Diseases / drug therapy*, immunology* Macrophage Colony-Stimulating Factor / antagonists & inhibitors Macrophages / drug effects, physiology* Molecular Targeted Therapy* Receptor, Macrophage Colony-Stimulating Factor / antagonists & inhibitors Receptors, IgG / antagonists & inhibitors Signal Transduction* / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Receptors, IgG; 81627-83-0/Macrophage Colony-Stimulating Factor; EC 2.7.10.1/Receptor, Macrophage Colony-Stimulating Factor; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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